Cannabinoid Cb1 Receptor Agonists Do Not Lower, But Might Increase Acoustic Trauma-induced Tinnitus In Pmc Rats
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SR knowledge for tinnitus evaluation were analyzed with LMM evaluation using a restricted maximum likelihood process (18–20, 23–25). Data had been analyzed with group (dummy vehicle, dummy drug, uncovered drug without tinnitus, or exposed drug with tinnitus) as a onerous and fast issue and intensity as a repeated measure. The Akaike data criterion was used to determine the most appropriate covariance structure. When appropriate, Bonferroni’s corrected post hoc checks had been used to make pairwise comparisons. The variety of animals with or with out behavioral proof of tinnitus was in contrast before, throughout, and after drug administration utilizing chi-square tests. Animals were exposed to unilateral acoustic trauma utilizing the methods described in our earlier publications (18–22).
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